The erythromycin breath test as a predictor of cyclosporine blood levels
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چکیده
منابع مشابه
The erythromycin breath test as a predictor of cyclosporine blood levels.
The daily dose of cyclosporine required to attain a desired blood level can vary greatly among patients. Because elimination of cyclosporine depends on its metabolism in the liver by an enzyme (cytochrome P-450IIIA) that also demethylates erythromycin, we reasoned that the ability of patients to demethylate a test dose of erythromycin might be useful in estimating their appropriate daily doses ...
متن کامل[C]erythromycin breath and urine test
Lemahieu, W. P. D., B. D. Maes, Y. Ghoos, P. Rutgeerts, K. Verbeke, and Y. Vanrenterghem. Measurement of hepatic and intestinal CYP3A4 and PGP activity by combined po iv [14C]erythromycin breath and urine test. Am J Physiol Gastrointest Liver Physiol 285: G470–G482, 2003; 10.1152/ajpgi.00028.2003.—The aim of the present study was to develop a test for measuring hepatic and intestinal removal of...
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Midazolam, a commonly used sedative and amnestic medication, has recently been shown to be largely metabolized in the liver by a cytochrome P450, termed CYP3A4. There is at least a tenfold intersubject variability in the liver content and catalytic activity of CYP3A4, which may in part account for the known interpatient differences in the kinetics of midazolam. To test this hypothesis, we deter...
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The erythromycin breath test (EBT) is a putative in vivo probe for drug metabolism by cytochrome P450 3A4 (CYP3A4). Because many anticancer drugs are metabolized by this system, we sought to further develop the EBT as a tool for predicting the clearance, in cancer patients, of drugs metabolized by CYP3A4. Sixteen adult patients with incurable cancer were studied. The EBT was performed on day 1 ...
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regarding the ever evolving and improving world on different aspects of knowledge, the need to a worldwide communication would emerge stronger than ever before which calls for special attention on the judgments and best choices for intermediating between the nations. as the language skills for translation are tested separately from translation skills themselves, to assess translation skills pro...
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ژورنال
عنوان ژورنال: Clinical Pharmacology and Therapeutics
سال: 1990
ISSN: 0009-9236,1532-6535
DOI: 10.1038/clpt.1990.126